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Genetic Health Screening

Multi-drug Sensitivity - MDR1

MDR1 or Multi-drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed dogs. This mutation can have a significant impact on drug sensitivity. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/ elimination of many drugs used in dogs. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

Technology Licensed By

The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test that has been licensed exclusively to Wisdom Health in the United States for use in the WISDOM PANELTM tests.

Washington State University

Further Extensive Disease Testing

In addition to the world’s largest breed database, the WISDOM PANEL Health test offers further extensive disease testing with screening for more than 150+ disease-causing mutations. This valuable information can help you work with your veterinarian to make a plan for your dog’s unique health and breed needs. Below is a full list of the disease mutations we test for by body system type.

Blood

  • Bleeding Disorder Due to P2RY12 Defect
  • Canine Leukocyte Adhesion Deficiency (CLAD), type III
  • Canine Scott Syndrome
  • Factor IX Deficiency or Hemophilia B; mutation Gly379Glu
  • Factor IX Deficiency or Hemophilia B; mutation originally found in Airedale Terrier
  • Factor IX Deficiency or Hemophilia B; mutation originally found in Lhasa Apso
  • Factor VII Deficiency
  • Factor VIII Deficiency or Hemophilia A; mutation originally found in Boxer
  • Factor VIII Deficiency or Hemophilia A; mutation originally found in German Shepherd Dog
  • Factor VIII Deficiency or Hemophilia A; mutation originally found in Havanese
  • Factor VIII Deficiency or Hemophilia A; p.Cys548Tyr mutation originally found in German Shepherd Dog
  • Factor XI Deficiency
  • Glanzmann Thrombasthenia Type I, (GT); mutation originally found in Great Pyrenees
  • Glanzmann Thrombasthenia Type I, (GT); mutation originally found in mixed breed dogs
  • Hereditary Elliptocytosis
  • Macrothrombocytopenia; disease-linked variant originally found in Norfolk and Cairn Terrier
  • May-Hegglin Anomaly, (MHA)
  • Phosphofructokinase (PFK) Deficiency or Glycogen Storage Disease Type VII
  • Prekallikrein Deficiency
  • Pyruvate Kinase Deficiency; mutation originally found in Beagle
  • Pyruvate Kinase Deficiency; mutation originally found in Pug
  • Pyruvate Kinase Deficiency; mutation originally found in West Highland White Terrier
  • Trapped Neutrophil Syndrome, (TNS)
  • von Willebrand's Disease (vWD) type 1; mutation originally found in Doberman Pinscher
  • von Willebrand's Disease (vWD) Type 3; mutation originally found in Scottish Terrier
  • von Willebrand's Disease (vWD) Type 3; mutation originally found in Shetland Sheepdog

Dental

  • Amelogenesis Imperfecta, (AI)
  • Dental Hypomineralization; mutation originally found in Border Collie

Drug response

  • Multidrug Resistance 1, (MDR1)

Eye

  • Canine Multifocal Retinopathy 1, (CMR1); mutation originally found in Mastiff-related breeds
  • Canine Multifocal Retinopathy 2, (CMR2); mutation originally found in Coton de Tulear
  • Cone Degeneration, (CD) or Achromatopsia; mutation originally found in Alaskan Malamute
  • Cone Degeneration, (CD) or Achromatopsia; mutation originally found in German Shepherd Dog
  • Cone Degeneration, (CD) or Achromatopsia; mutation originally found in German Shorthaired Pointer
  • Cone-Rod Dystrophy 1, (crd1); mutation originally found in American Staffordshire Terrier
  • Cone-Rod Dystrophy 2, (crd2); mutation originally found in American Pit Bull Terrier
  • Cone-Rod Dystrophy, mutation originally found in Standard Wirehaired Dachshund, (crd SWD)
  • Dominant Progressive Retinal Atrophy, (DPRA)
  • Golden Retriever Progressive Retinal Atrophy 2, (GR_PRA 2)
  • Primary Lens Luxation, (PLL)
  • Primary Open Angle Glaucoma and Primary Lens Luxation (POAG/PLL); mutation originally found in Chinese Shar-Pei
  • Primary Open Angle Glaucoma, (POAG); mutation originally found in Beagle
  • Progressive Retinal Atrophy Type III, (PRA type III); mutation originally found in Tibetan Spaniel and Tibetan Terrier
  • Progressive Retinal Atrophy, (CNGA1-PRA); mutation originally found in Shetland Sheepdog
  • Progressive Retinal Atrophy, (PAP1_PRA); mutation originally found in Papillon and Phalène
  • Rod-Cone Dysplasia 1, (rcd1); mutation originally found in Irish Setter
  • Rod-Cone Dysplasia 1a, (rcd1a); mutation originally found in Sloughi
  • Rod-Cone Dysplasia 3, (rcd3)
  • X-Linked Progressive Retinal Atrophy 2, (XLPRA2)

Heart

  • Dilated Cardiomyopathy, (DCM); mutation originally found in Standard Schnauzer
  • Long QT Syndrome

Hormonal

  • Congenital Hypothyroidism; mutation originally found in Tenterfield Terrier
  • Congenital Hypothyroidism; mutation originally found in Toy Fox and Rat Terrier

Immune system

  • Autosomal Recessive Severe Combined Immunodeficiency, (ARSCID)
  • Canine Cyclic Neutropenia, Cyclic Hematopoiesis, Gray Collie Syndrome, (CN)
  • Complement 3 (C3) Deficiency
  • X-linked Severe Combined Immunodeficiency, (XSCID); mutation originally found in Basset Hound
  • X-linked Severe Combined Immunodeficiency, (XSCID); mutation originally found in Cardigan Welsh Corgi

Lung

  • Acute Respiratory Distress Syndrome, (ARDS); mutation originally found in Dalmatian
  • Primary Ciliary Dyskinesia, (PCD)

Metabolic

  • Glycogen Storage Disease Type Ia, (GSD Ia)
  • Glycogen Storage Disease Type IIIa, (GSD IIIa); mutation originally found in Curly Coated Retriever
  • Hypocatalasia or Acatalasemia
  • Intestinal Cobalamin Malabsorption or Imerslund-Gräsbeck Syndrome, (IGS); mutation originally found in Beagle
  • Intestinal Cobalamin Malabsorption or Imerslund-Gräsbeck Syndrome, (IGS); mutation originally found in Border Collie
  • Mucopolysaccharidosis Type IIIA, (MPS IIIA); mutation originally found in Dachshund
  • Mucopolysaccharidosis Type VII, (MPS VII); mutation originally found in German Shepherd Dog
  • Pyruvate Dehydrogenase Phosphatase 1 (PDP1) Deficiency

Muscle

  • Cavalier King Charles Spaniel Muscular Dystrophy, (CKCS-MD)
  • Centronuclear Myopathy, (CNM); mutation originally found in Great Dane
  • Centronuclear Myopathy, (CNM); mutation originally found in Labrador Retriever
  • Duchenne or Dystrophin Muscular Dystrophy, (DMD); mutation originally found in Golden Retriever
  • Duchenne or Dystrophin Muscular Dystrophy, (DMD); mutation originally found in Norfolk Terrier
  • Muscular Dystrophy, Ullrich-type; mutation originally found in Landseer
  • Muscular Hypertrophy (Double Muscling)
  • Myotonia Congenita; mutation originally found in Australian Cattle Dog
  • Myotubular Myopathy; mutation originally found in Rottweiler
  • Nemaline Myopathy; mutation originally found in American Bulldog
  • X-Linked Myotubular Myopathy

Nervous system

  • Alaskan Husky Encephalopathy, (AHE)
  • Alexander Disease; mutation originally found in Labrador Retriever
  • Bandera's Neonatal Ataxia, (BNAt)
  • Benign Familial Juvenile Epilepsy or Remitting Focal Epilepsy
  • Cerebellar Cortical Degeneration, (CCD); mutation originally found in Vizsla
  • Cerebellar Hypoplasia; mutation originally found in Eurasier
  • Degenerative Myelopathy, (DM)
  • Fetal Onset Neuroaxonal Dystrophy, (FNAD)
  • Hereditary Ataxia or Cerebellar Ataxia; mutation originally found in Old English Sheepdog and Gordon Setter
  • Hyperekplexia or Startle Disease
  • Hypomyelination; mutation originally found in Weimaraner
  • Juvenile Laryngeal Paralysis and Polyneuropathy, (JLPP)
  • Juvenile Myoclonic Epilepsy; mutation originally found in Rhodesian Ridgeback
  • L-2-Hydroxyglutaric aciduria, (L2HGA); mutation originally found in Staffordshire Bull Terrier
  • L-2-Hydroxyglutaric aciduria, (L2HGA); mutation originally found in West Highland White Terrier
  • Lagotto Storage Disease, (LSD)
  • Narcolepsy; mutation originally found in Dachshund
  • Narcolepsy; mutation originally found in Labrador Retriever
  • Neonatal Cerebellar Cortical Degeneration or Cerebellar Abiotrophy, (NCCD)
  • Neonatal Encephalopathy with Seizures, (NEWS)
  • Neuroaxonal Dystrophy; mutation originally found in Spanish Water Dog
  • Neuronal Ceroid Lipofuscinosis 1, (NCL1); mutation originally found in Dachshund
  • Neuronal Ceroid Lipofuscinosis 10, (NCL10); mutation originally found in American Bulldog
  • Neuronal Ceroid Lipofuscinosis 7, (NCL7); mutation originally found in Chinese Crested Dog and Chihuahua
  • Neuronal Ceroid Lipofuscinosis 8, (NCL8); mutation originally found in Australian Shepherd
  • Neuronal Ceroid Lipofuscinosis 8, (NCL8); mutation originally found in English Setter
  • Sensory Ataxic Neuropathy, (SAN)
  • Sensory Neuropathy; mutation originally found in Border Collie
  • Spinal Dysraphism
  • Spinocerebellar Ataxia or Late-Onset Ataxia, (LOA)
  • Spinocerebellar Ataxia with Myokymia and/or Seizures, (SAMS)
  • Spongy Degeneration with Cerebellar Ataxia, (SDCA); mutation originally found in Belgian Shepherd
  • X-Linked Tremors; mutation originally found in English Springer Spaniel

Neuromuscular

  • Congenital Myasthenic Syndrome, (CMS); mutation originally found in Jack Russell Terrier
  • Congenital Myasthenic Syndrome, (CMS); mutation originally found in Labrador Retriever
  • Early-Onset Progressive Polyneuropathy; mutation originally found in Alaskan Malamute
  • Early-Onset Progressive Polyneuropathy; mutation originally found in Greyhound
  • Episodic Falling Syndrome, (EFS)
  • Exercise-Induced Collapse, (EIC)
  • Globoid Cell Leukodystrophy or Krabbe Disease, (GLD); mutation originally found in Irish Setter
  • Globoid Cell Leukodystrophy or Krabbe Disease, (GLD); mutation originally found in Terriers
  • GM2 Gangliosidosis; mutation originally found in Japanese Chin
  • GM2 Gangliosidosis; mutation originally found in Toy Poodle

Reproductive system

  • Persistent Müllerian Duct Syndrome, (PMDS); mutation originally found in Miniature Schnauzer

Skeletal

  • Chondrodysplasia; mutation originally found in Norwegian Elkhound and Karelian Bear Dog
  • Cleft Lip and Palate with Syndactyly (CLPS); originally found in Nova Scotia Duck Tolling Retriever
  • Cleft Palate (CP); originally found in Nova Scotia Duck Tolling Retriever
  • Craniomandibular Osteopathy, (CMO); mutation associated with terrier breeds
  • Hereditary Vitamin D-Resistant Rickets Type II, (HVDRR)
  • Musladin-Lueke Syndrome, (MLS)
  • Osteochondrodysplasia; mutation originally found in Miniature Poodle
  • Osteogenesis Imperfecta, (OI); mutation originally found in Beagle
  • Osteogenesis Imperfecta, (OI); mutation originally found in Dachshund
  • Skeletal Dysplasia 2, (SD2)
  • Spondylocostal Dysostosis
  • Van den Ende-Gupta Syndrome, (VDEGS)

Skin

  • Dystrophic Epidermolysis Bullosa; mutation originally found in Golden Retriever
  • Epidermolytic Hyperkeratosis
  • Focal Non-Epidermolytic Palmoplantar Keratoderma, (FNEPPK); mutation originally found in Dogue de Bordeaux
  • Hereditary Footpad Hyperkeratosis, (HFH)
  • Ichthyosis; mutation originally found in American Bulldog
  • Ichthyosis; mutation originally found in Great Dane
  • Lamellar Ichthyosis
  • Ligneous Membranitis
  • X-Linked Ectodermal Dysplasia, (XHED) or Anhidrotic Ectodermal Dysplasia

Urinary

  • Cystinuria Type I-A; mutation originally found in Newfoundland Dog
  • Cystinuria Type II-A; mutation originally found in Australian Cattle Dog
  • Fanconi Syndrome
  • Hyperuricosuria, (HUU)
  • Polycystic Kidney Disease, (PKD); mutation originally found in Bull Terrier
  • Protein Losing Nephropathy, (PLN); NPHS1 gene variant
  • Renal Cystadenocarcinoma and Nodular Dermatofibrosis, (RCND)
  • Xanthinuria, Type 1a
  • Xanthinuria, Type 2a; mutation originally found in Toy Manchester Terrier
  • X-Linked Hereditary Nephropathy, (XLHN); mutation originally found in Samoyed
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WISDOM PANEL Health screens for more than 150 genetic health conditions to help you keep on top of your dog’s healthcare needs.

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