Glanzmann Thrombasthenia Type I (Discovered in mixed breed dogs)

Glanzmann thrombasthenia causes susceptibility to bleeding due to poor blood platelet aggregation. This is caused by a deficiency in a platelet membrane glycoprotein. Typical clinical signs include mucosal bleeding, such as nose bleeds, bleeding from the gums, and intestinal bleeding, as well as blood in the urine. Blood spots under the skin or in the mouth may be observed. More severe, prolonged bleeding may occur due to a trauma or surgery. Glanzmann thrombasthenia can be suspected based on breed and typical clinical signs. In laboratory testing, the platelet count and clotting times are normal but the capillary bleeding time is prolonged. Please note bleeding tendency may be caused by a number of other causes affecting the clotting system. These causes include immune-mediated thrombocytopenia, anticoagulant rodenticide intoxications, disseminated intravascular coagulation, other hereditary bleeding disorders, and the use of certain drugs.

There is no curative treatment for the disease. Conservative treatment consists of prevention of bleeding and stopping active bleeding. The disorder must be taken into consideration when planning surgical intervention. Always inform your veterinarian about the disorder prior to surgery. In case of surgery or trauma induced bleeding, blood transfusions may be used to increase the amount of circulating platelets.

There are many responsibilities to consider when breeding dogs. Regardless of test results it is important that your dog is in good general health and that you are in a position to care for the puppies if new responsible owners are not found. For first time or novice breeders, advice can be found at most kennel club websites.

This disease is autosomal recessive meaning that two copies of the mutation are needed for disease signs to develop. A carrier dog with one copy of the GT mutation can be safely bred with a clear dog with no copies of the GT mutation. About half of the puppies will have one copy (carriers) and half will have no copies of the GT mutation. Puppies in a litter which is expected to contain carriers should be tested prior to breeding. Carrier to carrier matings are not advised as the resulting litter may contain affected puppies. Please note: It is possible that disease signs similar to the ones caused by the GT mutation could develop due to a different genetic or clinical cause.