Wisdom Panel 4.0 Kit
Wisdom Panel 4.0 Kit
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Wisdom Panel™ 4.0

Available EXCLUSIVELY on WisdomPanel.com
PRICE: $84.99


Discover the hidden secrets in your dog's DNA with the world's leading canine DNA test. Wisdom Panel 4.0 Canine DNA Test provides you with unprecedented accuracy to detect the breeds in your dog's ancestry as well as important health screens for drug sensitivity (MDR1) and Exercise-induced Collapse. Your dog's unique web site results portal will provide you with:

  1. Identification of purebred ancestors present in the first three generations (to the great-grandparent level)
  2. Extensive information about each breed found - behavior, traits, history
  3. A predicted weight profile
  4. Information about the physical traits your dog may exhibit
  5. Results for the drug-sensitivity genetic mutation, MDR1
  6. Results for Exercise-induced Collapse (EIC) screening

Wisdom Panel 4.0 tests feature the largest breed coverage available with more than 250 breeds, types and varieties including all those recognized by the American Kennel Club (AKC). Your dog's test kit will include:

  • Instructions
  • DNA cheek swabs – all for use on one dog
  • Drying insert for swabs
  • Pre-paid shipping label and box

Foreign Dogs+

Is your dog from a country outside the contiguous US, UK, Canada, Australia or Germany?

The Wisdom Panel test was developed using pure breeds primarily from those found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than Canada, the UK, Australia, Germany, or mainland U.S., or you suspect that your dog’s ancestors are from outside these countries, his breed ancestry may not be well represented in our database.

Breeds Detected+

As the leader in canine breed detection, Wisdom Panel 4.0 features the largest breed database on the market providing superior accuracy in breed results.
Don’t see your breed? Our database was developed using genetic markers from American Kennel Club (AKC) breeds and some breeds from the Kennel Club in the UK. If you believe your dog to be a breed or mix of breeds not found on this list note that his or her results may either show a mixed breed ancestor or the closest genetically related breed(s).
Afghan Hound
Airedale Terrier
Alaskan Klee Kai
Alaskan Malamute
American Bulldog
American English Coonhound
American Eskimo Dog
American Foxhound
American Hairless Terrier
American Staffordshire Terrier
American Water Spaniel
Anatolian Shepherd Dog
Argentine Dogo
Australian Cattle Dog
Australian Kelpie
Australian Koolie
Australian Shepherd
Australian Terrier
Basset Hound
Bearded Collie
Bedlington Terrier
Belgian Malinois
Belgian Sheepdog
Belgian Tervuren
Berger Picard
Bernese Mountain Dog
Bichon Frise
Biewer Terrier
Black and Tan Coonhound
Black Russian Terrier
Bluetick Coonhound
Border Collie
Border Terrier
Boston Terrier
Bouvier des Flandres
Boykin Spaniel
Brussels Griffon
Bull Terrier
Cairn Terrier
Canaan Dog
Canadian Eskimo Dog
Cane Corso
Cardigan Welsh Corgi
Catahoula Leopard Dog
Cavalier King Charles Spaniel
Cesky Terrier
Chesapeake Bay Retriever
Chinese Crested
Chinese Shar-Pei
Chow Chow
Cirneco dell'Etna
Clumber Spaniel
Cocker Spaniel
Coton de Tulear
Curly-Coated Retriever
Dachshund -  Miniature, Standard, Smooth, Longhair & Wirehair
Dandie Dinmont Terrier
Doberman Pinscher
Dogue De Bordeaux
Dutch Shepherd Dog
English Cocker Spaniel
English Foxhound
English Setter
English Springer Spaniel
English Toy Spaniel
Entlebucher Mountain Dog
Field Spaniel
Finnish Lapphund
Finnish Spitz
Flat-Coated Retriever
French Bulldog
German Pinscher
German Shepherd Dog
German Shorthaired Pointer
German Spitz
German Wirehaired Pointer
Giant Schnauzer
Glen of Imaal Terrier
Golden Retriever
Gordon Setter
Grand Basset Griffon Vendeen
Great Dane
Great Pyrenees
Greater Swiss Mountain Dog
Ibizan Hound
Icelandic Sheepdog
Irish Red and White Setter
Irish Setter
Irish Terrier
Irish Water Spaniel
Irish Wolfhound
Italian Greyhound
Japanese Chin
Japanese Spitz
Kerry Blue Terrier
Labrador Retriever
Lagotto Romagnolo
Lakeland Terrier
Lancashire Heeler
Large Münsterlander
Lhasa Apso
Manchester Terrier - Standard & Toy
Maremma Sheepdog
Miniature American Shepherd
Miniature Bull Terrier
Miniature Pinscher
Miniature Schnauzer
Murray River Retriever
Neapolitan Mastiff
Norfolk Terrier
Norwegian Buhund
Norwegian Elkhound
Norwegian Lundehund
Norwich Terrier
Nova Scotia Duck Tolling Retriever
Old English Sheepdog
Parson Russell Terrier
Pembroke Welsh Corgi
Petit Basset Griffon Vendeen
Pharaoh Hound
Plott Hound
Polish Lowland Sheepdog
Poodle - Miniature, Standard & Toy
Portuguese Podengo Pequeno
Portuguese Water Dog
Presa Canario
Pyrenean Shepherd
Rat Terrier
Redbone Coonhound
Rhodesian Ridgeback
Russell Terrier
Russian Tsvetnaya Bolonka
Saint Bernard
Scottish Deerhound
Scottish Terrier
Sealyham Terrier
Shetland Sheepdog
Shiba Inu
Shih Tzu
Siberian Husky
Silky Terrier
Skye Terrier
Small Münsterlander
Smooth Fox Terrier
Soft Coated Wheaten Terrier
Spanish Water Dog
Spinone Italiano
Staffordshire Bull Terrier
Standard Schnauzer
Sussex Spaniel
Swedish Vallhund
Tibetan Mastiff
Tibetan Spaniel
Tibetan Terrier
Toy Fox Terrier
Treeing Walker Coonhound
Welsh Springer Spaniel
Welsh Terrier
West Highland White Terrier
White Swiss Shepherd
Wire Fox Terrier
Wirehaired Pointing Griffon
Wirehaired Vizsla
Yorkshire Terrier

Health Screens+

MDR1 Disease Screening

For many years now Wisdom Panel has provided genetic mutation tests through our veterinary products and now we are including one of these important tests in our at-home swab product. Included in the Wisdom Panel 3.0 and 4.0 Canine Genetic Tests is the MDR1 genetic mutation test licensed from Washington State University, for use by Wisdom Health.

MDR1 or Multi-Drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.

Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

What About Mixed-breed Dogs?

Our tests look for the presence of purebreds in your dog’s heritage back to the great-grandparent level. Just because we don’t find a pedigree herding breed in your dog’s last three generations, however, doesn’t mean he or she doesn’t have one further back in their ancestry. Therefore, even mixed breed dogs should be tested for the MDR1 mutation. The results of this test can give owners with mixed-breed ancestry important information to share with their veterinarian or better yet…peace of mind.

Drugs Affected By The MDR1 Mutation:


Drugs Affected By The MDR1 Mutation (frequency %)

Australian Shepherd 50%
Australian Shepherd, Mini 50%
Border Collie < 5%
Collie 70 %
English Shepherd 15 %
German Shepherd 10 %
Herding Breed Cross 10 %
Long-haired Whippet 65 %
McNab 30 %
Mixed Breed 5 %
Old English Sheepdog 5 %
Shetland Sheepdog 15 %
Silken Windhound 30 %


Can Collie crosses or other herding breed crosses carry the mutant MDR1 gene and have an adverse reaction to a normal dose of some drugs?

Yes, it is less likely in a mixed breed, but still possible. For example, the mutant gene was found in a Saint Bernard mix that had an adverse drug reaction. The veterinarian did note that each eye was a different color, like some Australian Shepherds.

How old must a dog be before it can be tested?

Just like breed testing, a puppy can be tested as soon as it is weaned from its mother. We recommend waiting until the puppy is weaned, because the sample is collected from inside the dog's mouth, and milk can contain a cells from the mother. Therefore, it is possible that the puppy's sample could contain enough of the mother’s DNA to generate a false result.

Can mixed breed dogs have the MDR1 mutation?

YES! The MDR1 mutation has been found in many mixed breed dogs - even dogs that don't look like herding breed dogs. In particular mixed breed dogs should be tested for the mutation before receiving therapies for some common parasitic diseases, such as Demodectic mange.

What heartworm prevention products can I use if my dog has the MDR1 mutation?

Always consult with your veterinarian before administering any drugs to your dog. Fortunately, the doses of ivermectin, selamectin, milbemycin and moxidectin in the FDA approved heartworm prevention preparations are low enough to be used safely even in dogs that have two copies of the MDR1 mutation. It is only when these drugs are administered at high doses that dogs with the mutation will develop signs of toxicity. Attempting to use formulations of these drugs approved for use in large animals will increase the risk of overdosing the dog and causing severe toxicity, because it is difficult to accurately measure the small doses needed for dogs using these large animal formulations.


The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test offered by Washington State University that has been licensed to Wisdom Health for use in the Wisdom Panel tests.

Exercise-Induced Collapse

Clinical Overview

Exercise-induced collapse (EIC) is an inherited disorder of nerve and muscle that was first identified in Labrador Retrievers. It is caused by a mutation in the DNM1 gene, and is characterized by exercise intolerance in otherwise normal dogs.

Clinical Signs and Severity

Signs are usually first noted in young dogs, most frequently between 5 months and 3 years of age. Affected dogs appear normal during low to moderate exercise, but develop clinical signs including weakness, wobbliness, and incoordination after strenuous exercise, particularly in the hind limbs. In severe cases, short-term full body collapse and muscle weakness can be noted. The episodes typically last 5-10 minutes, and most dogs will recover completely within 15-30 minutes.

Severity of the disorder is mild to moderate for the majority of dogs. Dogs are not painful during collapse or after recovery. Affected dogs are generally unable to continue training or competition, but can live relatively normal lives if exercise and excitement are limited.

Factors Contributing to Collapse in Affected Dogs

  • Ambient temperature or humidity much higher than what the dog is used to
  • Extreme excitement or stress
  • Exercise that is continuous, intense, and accompanied by high level excitement or anxiety

Commonly Affected Breeds

  • Boykin Spaniel
  • Chesapeake Bay Retriever
  • Curly Coated Retriever
  • Labrador Retriever
  • Old English Sheepdog
  • Pembroke Welsh Corgi
  • German Wirehaired Pointer
  • Mixed-breed


OPEN SWAB SLEEVE – Peel back the edges of the swab sleeve about 1 inch (not all the way) and remove swab by holding its handle. Do not touch the bristles. Save the sleeve to place the swabs in for mailing.
COLLECT CHEEK CELLS – Firmly roll the swab’s bristles between the inner surface of the cheek and gums for about 15 seconds for each swab. NOTE: DO NOT let your dog eat anything for about an hour before you do the test.
AIR DRY SWABS – Insert swab handle in the hole of the carton insert and allow swabs to dry for about five minutes. Repeat steps 1-3 for the second swab.
ACTIVATE YOUR KIT – Visit www.wisdompanel.com and click on the "Activate Your Kit" button at the top of the page. Fill out all the information, check it for accuracy and submit. You will receive an Activation Code Number that you need to write on the back of your Sample ID Sticker.
REINSERT DRY SWABS – Reinsert both dry swabs into the protective sleeve they came in. DO NOT reseal as this can cause bacterial growth.
SEAL THE CARTON – Place the sleeve with the swabs back into the carton it came in and seal.
MAIL TEST TO LAB – Pre-paid shipping label has already been placed on the carton.  Simply seal and place with the outgoing mail. IN APPROXIMATELY 2-3 WEEKS FROM THE TIME THE SAMPLE REACHES THE LAB YOU WILL BE EMAILED A LINK TO DOWNLOAD YOUR REPORT.


Missed breeds


I ran two DNA tests on this particular pup, Wisdom Panel and Embark. I knew that the pups mother has traceable breeding back to a German Shepherd/Doberman mix but we knew nothing of the father dog of this litter or the father dog of the mothers litter. So thus we wanted to do a DNA test and see what else was in there. Embark did catch these two breeds (German Shepherd/Doberman) but Wisdom Panel 4.0 COMPLETELY missed them. So I really am questioning the accuracy of this test. We have also done tests on sibling pups and all of them came up with the German Shepherd/Doberman genes. What gives?


Seattle, Wa


We got a boxer mix and we were shocked with our DNA results!


We had some difficulty wrangling our 4 month old puppy to get the cheek swabs. We should have waited until he was sleeping but we were too impatient. The results were shocking! We got him from a family who had him for a month before deciding they couldn't take care of him anymore and they said the person they got him from said he was full boxer but she knew he didn't look full boxer and must have been boxer mix. The results came back with NO boxer! He is 50% American Staffordshire Terrier, 12.5%Cocker Spaniel, 12.5% Schnauzer. It took some time and googling a thousand photos of Amstaffs with his same coloring for me to believe the results. We had someone who specializes in Cocker Spaniels tell us before we got the results that he had a Cocker Spaniel body (I thought they were crazy!) and our vet thought he was boxer/beagle. But nope! He's an Amstaffernauzer as I call him now 🙂 I definitely recommend this. It's great to know what breeds really make up your pup.


Pittsburgh, PA


Everyone with a mixed breed dog should do this!


We adopted a middle aged (owner surrendered) dog. I was told she was half Newfoundland and half Husky. She looked like a wolf so I decided to test her :). The results came back 50% Newfoundland and 50% Husky, just as I was told!

Tia the non wolf

Southport, CT


Very interesting


This was a lot of fun to read through regarding our dogs. I esp. liked the genetic marker details which described how one gene would obscure another's expression. Pretty accurate, esp. since they have no idea what my dog looks like.


Coastal New Jersey


Worth every penny


I ordered the kit to understand my dog better. She's a rescue whose father's identity was a mystery. I already knew the breed of the mother. The results exceeded my expectations. Not only did it accurately determine the mother's lineage but it also correctly predicted her physical traits (such as coat color, facial markings, tail length) based purely on her genetic info. It was definitely worth the purchase, even if it was just for intellectual curiosity.


San Jose, CA


Much better than ten years ago


So much more precise and useful than when I had one run ten years ago on another dog. Thanks!

Possum and Taters' mom

Silver Spring MD


You never know what you have


Very easy to use, just brush against the inside of your pets cheek and send it in. We were always told that Buddy was fat or too big for what we thought he was. After getting his DNA test results back we now know why he is a big boy. We thought he was Lab and Border Collie (which he is) but he is also German Shepard and part Great Pyrenees. We love knowing what he really is instead of just guessing. Thank you Wisdom Panel.


Fort Dick, CA


forgot password had trouble getting back


Forgot password and very difficult to get back in. But otherwise interesting


Oneonta NY


Mystery Solved


Our Heinz 57 rescue dog has been a sweetheart from day one. We were so curious to put some identity to her lovable appearance and demeanor. Found out she is 25% pure dachshund which not one person ever predicted but all other components are truly mixed breed. Wisdom Panel was easy to use and I feel quite accurate. It helped to read several other reviews esp. the one from a biology pro who offered lots of insight.

Emma, the mutt's ,mom

New Ulm. MN


Everyone Had Guessed Wrong!


My pup was larger in body than most of her Beagle breed, longer, and so people assumed Dachshund. But no, that body came from a Boxer way back in her DNA that mated with a Chow Chow!!! When I could not get my report to come up, Wisdom worked with me via email and finally made a copy of my report and mailed it to me. That was going above and beyond. Very happy with the results and I had done this with my previous dog and was very happy with those results as well.


Richmond, VA


Wisdom Panel

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