Domestic Longhair

Domestic Longhair Genetic Health Conditions

• Pyruvate Kinase Deficiency

  Pyruvate Kinase (PK) Deficiency is a disorder that causes anemia due to the breakdown of red blood cells.

• Mucopolysaccharidosis Type VII (Variant 2)

  Mucopolysaccharidosis Type VII is a disorder causing weakness, growth retardation, facial and other skeletal abnormalities, and clouding of the eyes.

• Glutaric Aciduria Type II

  Glutaric Aciduria Type II causes loss of appetite, vomiting and seizures in young cats.

• Cystinuria Type B (Variant 3)

  Cystinuria is a condition that predisposes cats to form cystine crystals and stones within the urinary tract, which can then cause irritation and blockage.

• Polycystic Kidney Disease (PKD)

  Polycystic Kidney Disease (PKD) is the most common inherited disease in cats. The disease causes the formation of fluid-filled cysts in the kidneys that can lead to kidney failure.

• Lipoprotein Lipase Deficiency

  Lipoprotein Lipase Deficiency is a metabolic disorder that causes decreased body mass and reduced growth rates in affected kittens and can cause stillbirths in affected queens.

• MDR1 Medication Sensitivity

  MDR1 Medication Sensitivity is a disorder caused by a defect to a drug pumping protein that plays an important role in limiting drug absorption and distribution (particularly to the brain). Cats with the MDR1 variant may have severe adverse reactions to some commonly used medications.

• Cystinuria Type B (Variant 2)

  Cystinuria is a condition that predisposes cats to form cystine crystals and stones within the urinary tract, which can then cause irritation and blockage.

• Cystinuria Type B (Variant 1)

  Cystinuria is a condition that predisposes cats to form cystine crystals and stones within the urinary tract, which can then cause irritation and blockage.

• Factor XII Deficiency (Variant 2)

  Factor XII Deficiency, also known as Hageman trait, is an asymptomatic blood factor deficiency. While it does not cause an abnormal tendency to bleed, it can be observed as prolonged blood clotting times during certain laboratory screening tests.

• Myotonia Congenita

  Myotonia Congenita is a condition that results in stiff movement and delayed relaxation of muscles after exercise.

• Acute Intermittent Porphyria (Variant 2)

  Acute Intermittent Porphyria (AIP) is caused by faulty enzyme activity and results in brownish discoloration of the teeth and urine in affected cats.

• Acute Intermittent Porphyria (Variant 5)

  Acute Intermittent Porphyria (AIP) is caused by faulty enzyme activity and results in brownish discoloration of the teeth and urine in affected cats.

• GM1 Gangliosidosis

  GM1 Gangliosidosis causes muscle tremors, uncoordinated movements, and blindness.

• Hyperoxaluria Type II

  Hyperoxaluria Type II is a kidney disorder leading to severe weakness and kidney failure in young cats.

• Vitamin D-Dependent Rickets

  Vitamin D-Dependent Rickets results in skeletal abnormalities caused by low blood calcium levels.

• Hemophilia B (Variant 2)

  Hemophilia B, or Factor IX Deficiency, is a blood clotting disorder that can result in tiredness, decreased appetite, fever, lameness, and prolonged bleeding times after injury, trauma or surgery.

• Mucopolysaccharidosis Type VI Modifier

  Mucopolysaccharidosis Type VI Modifier causes a mild degenerative joint disease, but only if one copy of Mucopolysaccharidosis Type VI is also present.

• Congenital Erythropoietic Porphyria

  Congenital Erythropoietic Porphyria (CEP) is caused by faulty enzyme activity and results in brownish discoloration of the teeth and urine in affected cats.

• Mucopolysaccharidosis Type I

  Mucopolysaccharidosis Type I is a disorder causing failure to thrive, facial and other skeletal abnormalities, tremors, and clouding of the eyes.

• Sphingomyelinosis (Variant 2)

  Sphingomyelinosis causes progressive incoordination and tremors, enlargement of the spleen and liver, and changes in the lungs.

• Hemophilia B (Variant 1)

  Hemophilia B, or Factor IX Deficiency, is a blood clotting disorder that can result in tiredness, decreased appetite, fever, lameness, and prolonged bleeding times after injury, trauma or surgery.

• GM2 Gangliosidosis

  GM2 Gangliosidosis causes muscle tremors, uncoordinated movements, difficulty eating, and blindness.

• Mucopolysaccharidosis Type VI

  Mucopolysaccharidosis Type VI is a rare disorder causing dwarfism, degenerative joint disease, and clouding of the eyes.

• Dihydropyrimidinase Deficiency

  Dihydropyrimidinase Deficiency is a condition that causes tiredness, weakness, vomiting, and high levels of ammonia in the blood.

• Sphingomyelinosis (Variant 1)

  Sphingomyelinosis causes progressive incoordination and tremors, enlargement of the spleen and liver, and changes in the lungs.

• Mucopolysaccharidosis Type VII (Variant 1)

  Mucopolysaccharidosis Type VII is a disorder causing weakness, growth retardation, facial and other skeletal abnormalities, and clouding of the eyes.

• GM2 Gangliosidosis Type II (Discovered in Domestic Shorthair cats)

  GM2 Gangliosidosis Type II causes muscle tremors, uncoordinated movements, difficulty eating, and blindness.

• Congenital Adrenal Hyperplasia

  Congenital Adrenal Hyperplasia is an endocrine disorder which leads to aggression, abnormalities of the genitalia, and excessive drinking and urination.

• Earfold and Osteochondrodysplasia (Discovered in the Scottish Fold)

  The Earfold and Osteochondrodysplasia variant results in the breed defining folded ears of Scottish Fold cats and is associated with skeletal malformations and arthritis.

• Acute Intermittent Porphyria (Variant 1)

  Acute Intermittent Porphyria (AIP) is caused by faulty enzyme activity and results in brownish discoloration of the teeth and urine in affected cats.

• Cystinuria Type 1A

  Cystinuria is a condition that predisposes cats to form cystine crystals and stones within the urinary tract, which can then cause irritation and blockage.

With more than 45 health tests, Wisdom Panel™ Complete for Cats screens for these and other important genetic conditions—allowing you to better plan for your cat's lifelong care.