Leo Dog

Disease Screening

 
Scientific Legacy

Multi-drug Sensitivity – MDR1

MDR1 or Multi-drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed-breed dogs. This mutation can have a significant impact on drug sensitivity. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

Technology Licensed By

The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test that has been licensed exclusively to Wisdom Health in the United States for use in the Wisdom Panel™ tests.

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Further Extensive Disease Testing!

In addition to the world’s largest breed database, Wisdom Panel Health test now offers extensive disease testing, screening for more than 140+ disease-causing mutations. This valuable information can help you work with your veterinarian to make a plan for your dog’s unique health and breed needs. Below is a full list of the disease mutations we test for by body system type.
Blood
Bleeding disorder due to P2RY12 defect
Canine Scott Syndrome
Factor IX Deficiency or Hemophilia B; mutation Gly379Glu
Factor IX Deficiency or Hemophilia B; mutation originally found in Airedale Terrier
Factor IX Deficiency or Hemophilia B; mutation originally found in Lhasa Apso
Factor VII Deficiency
Factor VIII Deficiency or Hemophilia A; mutation originally found in Boxer
Factor VIII Deficiency or Hemophilia A; mutation originally found in German Shepherd Dog
Factor VIII Deficiency or Hemophilia A; mutation originally found in Havanese
Factor VIII Deficiency or Hemophilia A; p.Cys548Tyr mutation originally found in German Shepherd Dog
Factor XI Deficiency
Glanzmann Thrombasthenia Type I, (GT); mutation originally found in Great Pyrenees
Hereditary Elliptocytosis
Macrothrombocytopenia; disease-linked variant originally found in Norfolk and Cairn Terrier
May-Hegglin Anomaly, (MHA)
Phosphofructokinase (PFK) Deficiency or Glycogen Storage Disease Type VII
Prekallikrein Deficiency
Pyruvate Kinase Deficiency; mutation originally found in Beagle
Pyruvate Kinase Deficiency; mutation originally found in Pug
Pyruvate Kinase Deficiency; mutation originally found in West Highland White Terrier
Trapped Neutrophil Syndrome, (TNS)
von Willebrand's Disease (vWD) Type 1; mutation originally found in Doberman Pinscher
von Willebrand's Disease (vWD) Type 2; mutation originally found in German Wirehaired Pointer
von Willebrand's Disease (vWD) Type 3; mutation originally found in Kooiker Hound
Dental
Amelogenesis Imperfecta, (AI)
Dental Hypomineralization; mutation originally found in Border Collie
Drug response
Multidrug Resistance 1, (MDR1)
Eye
Canine Multifocal Retinopathy 1, (CMR1); mutation originally found in Mastiff-related breeds
Canine Multifocal Retinopathy 2, (CMR2); mutation originally found in Coton de Tulear
Canine Multifocal Retinopathy 3, (CMR3); mutation originally found in Lapponian Herder
Cone Degeneration, (CD) or Achromatopsia; mutation originally found in Alaskan Malamute
Cone Degeneration, (CD) or Achromatopsia; mutation originally found in German Shepherd Dog
Cone Degeneration, (CD) or Achromatopsia; mutation originally found in German Shorthaired Pointer
Cone-Rod Dystrophy 1, (crd1); mutation originally found in American Staffordshire Terrier
Cone-Rod Dystrophy 2, (crd2); mutation originally found in American Pit Bull Terrier
Cone-Rod Dystrophy, mutation originally found in Standard Wirehaired Dachshund, (crd SWD)
Dominant Progressive Retinal Atrophy, (DPRA)
Golden Retriever Progressive Retinal Atrophy 2, (GR_PRA 2)
Primary Lens Luxation, (PLL)
Primary Open Angle Glaucoma, (POAG); mutation originally found in Beagle
Progressive Retinal Atrophy Type III, (PRA type III); mutation originally found in Tibetan Spaniel and Tibetan Terrier
Progressive Retinal Atrophy, (CNGA1-PRA); mutation originally found in Shetland Sheepdog
Progressive Retinal Atrophy, (PAP1_PRA); mutation originally found in Papillon and Phalène
Rod-Cone Dysplasia 1, (rcd1); mutation originally found in Irish Setter
Rod-Cone Dysplasia 1a, (rcd1a); mutation originally found in Sloughi
Rod-Cone Dysplasia 3, (rcd3)
X-Linked Progressive Retinal Atrophy 2, (XLPRA2)
Heart
Long QT Syndrome
Hormonal
Congenital Hypothyroidism; mutation originally found in Tenterfield Terrier
Congenital Hypothyroidism; mutation originally found in Toy Fox and Rat Terrier
Immune system
Autosomal Recessive Severe Combined Immunodeficiency, (ARSCID)
Canine Cyclic Neutropenia, Cyclic Hematopoiesis, Gray Collie Syndrome, (CN)
Complement 3 (C3) Deficiency
Myeloperoxidase Deficiency; mutation originally found in Italian Hound
Severe Combined Immunodeficiency, (SCID); mutation originally found in Frisian Water Dogs
X-linked Severe Combined Immunodeficiency, (XSCID); mutation originally found in Basset Hound
X-linked Severe Combined Immunodeficiency, (XSCID); mutation originally found in Cardigan Welsh Corgi
Lung
Primary Ciliary Dyskinesia, (PCD)
Metabolism
Glycogen Storage Disease Type Ia, (GSD Ia)
Hypocatalasia or Acatalasemia
Intestinal Cobalamin Malabsorption or Imerslund-Gräsbeck Syndrome, (IGS); mutation originally found in Beagle
Intestinal Cobalamin Malabsorption or Imerslund-Gräsbeck Syndrome, (IGS); mutation originally found in Border Collie
Mucopolysaccharidosis Type IIIA, (MPS IIIA); mutation originally found in Dachshund
Mucopolysaccharidosis Type VII, (MPS VII); mutation originally found in Brazilian Terrier
Mucopolysaccharidosis Type VII, (MPS VII); mutation originally found in German Shepherd Dog
Pyruvate Dehydrogenase Phosphatase 1 (PDP1) Deficiency
Muscle
Cavalier King Charles Spaniel Muscular Dystrophy, (CKCS-MD)
Centronuclear Myopathy, (CNM); mutation originally found in Great Dane
Centronuclear Myopathy, (CNM); mutation originally found in Labrador Retriever
Duchenne or Dystrophin Muscular Dystrophy, (DMD); mutation originally found in Golden Retriever
Duchenne or Dystrophin Muscular Dystrophy, (DMD); mutation originally found in Norfolk Terrier
Muscular Dystrophy, Ullrich-type; mutation originally found in Landseer
Muscular Hypertrophy (Double Muscling)
Myotonia Congenita; mutation originally found in Australian Cattle Dog
Myotubular Myopathy; mutation originally found in Rottweiler
Nervous system
Alaskan Husky Encephalopathy, (AHE)
Bandera's Neonatal Ataxia, (BNAt)
Benign Familial Juvenile Epilepsy or Remitting Focal Epilepsy
Cerebellar Hypoplasia; mutation originally found in Eurasier
Cerebral Dysfunction; mutation originally found in Frisian Stabyhoun
Degenerative Myelopathy, (DM)
Fetal Onset Neuroaxonal Dystrophy, (FNAD)
Hereditary Ataxia or Cerebellar Ataxia; mutation originally found in Old English Sheepdog and Gordon Setter
Hyperekplexia or Startle Disease
Hypomyelination; mutation originally found in Weimaraner
L-2-Hydroxyglutaric aciduria, (L2HGA); mutation originally found in Staffordshire Bull Terrier
Lagotto Storage Disease, (LSD)
Narcolepsy; mutation originally found in Dachshund
Narcolepsy; mutation originally found in Labrador Retriever
Neonatal Cerebellar Cortical Degeneration or Cerebellar Abiotrophy, (NCCD)
Neonatal Encephalopathy with Seizures, (NEWS)
Neuroaxonal Dystrophy; mutation originally found in Spanish Water Dog
Neuronal Ceroid Lipofuscinosis 1, (NCL1); mutation originally found in Dachshund
Neuronal Ceroid Lipofuscinosis 10, (NCL10); mutation originally found in American Bulldog
Neuronal Ceroid Lipofuscinosis 7, (NCL7); mutation originally found in Chinese Crested Dog and Chihuahua
Neuronal Ceroid Lipofuscinosis 8, (NCL8); mutation originally found in Australian Shepherd
Neuronal Ceroid Lipofuscinosis 8, (NCL8); mutation originally found in English Setter
Progressive Early-Onset Cerebellar Ataxia; mutation originally found in Finnish Hound
Sensory Ataxic Neuropathy, (SAN)
Spinal Dysraphism
Spinocerebellar Ataxia or Late-Onset Ataxia, (LOA)
Spinocerebellar Ataxia with Myokymia and/or Seizures, (SAMS)
X-Linked Tremors; mutation originally found in English Springer Spaniel
Neuromuscular
Congenital Myasthenic Syndrome, (CMS); mutation originally found in Jack Russell Terrier
Congenital Myasthenic Syndrome, (CMS); mutation originally found in Labrador Retriever
Congenital Myasthenic Syndrome, (CMS); mutation originally found in Old Danish Pointing Dog
Early-Onset Progressive Polyneuropathy; mutation originally found in Alaskan Malamute
Early-Onset Progressive Polyneuropathy; mutation originally found in Greyhound
Episodic Falling Syndrome, (EFS)
Exercise-Induced Collapse, (EIC)
Globoid Cell Leukodystrophy or Krabbe Disease, (GLD); mutation originally found in Irish Setter
Globoid Cell Leukodystrophy or Krabbe Disease, (GLD); mutation originally found in Terriers
GM2 Gangliosidosis; mutation originally found in Japanese Chin
GM2 Gangliosidosis; mutation originally found in Toy Poodle
Reproductive system
Persistent Müllerian Duct Syndrome, (PMDS); mutation originally found in Miniature Schnauzer
Skeletal
Bobtail
Chondrodysplasia; mutation originally found in Norwegian Elkhound and Karelian Bear Dog
Cleft Lip and Palate with Syndactyly (CLPS); originally found in Nova Scotia Duck Tolling Retriever
Cleft Palate (CP); originally found in Nova Scotia Duck Tolling Retriever
Craniomandibular Osteopathy, (CMO); mutation associated with terrier breeds
Hereditary Vitamin D-Resistant Rickets Type II, (HVDRR)
Musladin-Lueke Syndrome, (MLS)
Osteochondrodysplasia; mutation originally found in Miniature Poodle
Osteogenesis Imperfecta, (OI); mutation originally found in Beagle
Osteogenesis Imperfecta, (OI); mutation originally found in Dachshund
Skeletal Dysplasia 2, (SD2)
Spondylocostal Dysostosis
Van den Ende-Gupta Syndrome, (VDEGS)
Skin
Dystrophic Epidermolysis Bullosa; mutation originally found in Central Asian Ovcharka
Dystrophic Epidermolysis Bullosa; mutation originally found in Golden Retriever
Epidermolytic Hyperkeratosis
Focal Non-Epidermolytic Palmoplantar Keratoderma, (FNEPPK); mutation originally found in Dogue de Bordeaux
Harlequin Coat Pattern
Hereditary Footpad Hyperkeratosis, (HFH)
Ichthyosis; mutation originally found in Great Dane
Lamellar Ichthyosis
Ligneous Membranitis
X-Linked Ectodermal Dysplasia, (XHED) or Anhidrotic Ectodermal Dysplasia
Urinary
Cystinuria Type I-A; mutation originally found in Newfoundland Dog
Cystinuria Type II-A; mutation originally found in Australian Cattle Dog
Fanconi Syndrome
Hyperuricosuria, (HUU)
Polycystic Kidney Disease, (PKD); mutation originally found in Bull Terrier
Protein Losing Nephropathy, (PLN); NPHS1 gene variant
Renal Cystadenocarcinoma and Nodular Dermatofibrosis, (RCND)
X-Linked Hereditary Nephropathy, (XLHN); mutation originally found in Navasota Dog
X-Linked Hereditary Nephropathy, (XLHN); mutation originally found in Samoyed