Wisdom Panel 4.0
Wisdom Panel 4.0
Alternative Views
  • Ancestry
  • MDR1
  • Report
  • Wisdom Panel 4.0

  • alt view name
  • alt view name
  • alt view name
  • alt view name

Wisdom Panel® 4.0

PRICE: $84.99


The Wisdom Panel 4.0 Canine DNA Test provides you with information to plan for your dog’s unique nutrition, training and even healthcare. Results provide you with:

  1. Ancestry back to the great-grandparent level
  2. A predicted weight profile
  3. Information about the physical traits your dog may exhibit
  4. Testing for the MDR1 genetic mutation
  5. Testing for Exercise-induced Collapse (EIC)

Wisdom Panel 4.0 covers more than 250 breeds, types and varieties including all those recognized by the American Kennel Club (AKC) and can be run for mixed-breed, designer, or purebred dogs. The procedure is the same for all three, but you decide at the time of activation how you would like us to run it. For purebred and designer dogs, the test will provide a Principle Component Analysis chart comparing your dog with others of that same breed(s) in our database and for purebred tests specifically, an additional Homozygosity Profile.

The Wisdom Panel 4.0 Canine DNA Test Kit includes:

  • Instructions
  • DNA cheek swabs – all for use on one dog
  • Drying insert for swabs
  • Pre-paid shipping label and box

Health Screens+

MDR1 Disease Screening

For many years now Wisdom Panel has provided genetic mutation tests through our veterinary products and now we are including one of these important tests in our at-home swab product. Included in the Wisdom Panel 3.0 and 4.0 Canine Genetic Tests is the MDR1 genetic mutation test licensed from Washington State University, for use by Mars Veterinary.

MDR1 or Multi-Drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.

Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

What About Mixed-breed Dogs?

Our tests look for the presence of purebreds in your dog’s heritage back to the great-grandparent level. Just because we don’t find a pedigree herding breed in your dog’s last three generations, however, doesn’t mean he or she doesn’t have one further back in their ancestry. Therefore, even mixed breed dogs should be tested for the MDR1 mutation. The results of this test can give owners with mixed-breed ancestry important information to share with their veterinarian or better yet…peace of mind.

Drugs Affected By The MDR1 Mutation:


Drugs Affected By The MDR1 Mutation (frequency %)

Australian Shepherd 50%
Australian Shepherd, Mini 50%
Border Collie < 5%
Collie 70 %
English Shepherd 15 %
German Shepherd 10 %
Herding Breed Cross 10 %
Long-haired Whippet 65 %
McNab 30 %
Mixed Breed 5 %
Old English Sheepdog 5 %
Shetland Sheepdog 15 %
Silken Windhound 30 %


Can Collie crosses or other herding breed crosses carry the mutant MDR1 gene and have an adverse reaction to a normal dose of some drugs?

Yes, it is less likely in a mixed breed, but still possible. For example, the mutant gene was found in a Saint Bernard mix that had an adverse drug reaction. The veterinarian did note that each eye was a different color, like some Australian Shepherds.

How old must a dog be before it can be tested?

Just like breed testing, a puppy can be tested as soon as it is weaned from its mother. We recommend waiting until the puppy is weaned, because the sample is collected from inside the dog's mouth, and milk can contain a cells from the mother. Therefore, it is possible that the puppy's sample could contain enough of the mother’s DNA to generate a false result.

Can mixed breed dogs have the MDR1 mutation?

YES! The MDR1 mutation has been found in many mixed breed dogs - even dogs that don't look like herding breed dogs. In particular mixed breed dogs should be tested for the mutation before receiving therapies for some common parasitic diseases, such as Demodectic mange.

What heartworm prevention products can I use if my dog has the MDR1 mutation?

Always consult with your veterinarian before administering any drugs to your dog. Fortunately, the doses of ivermectin, selamectin, milbemycin and moxidectin in the FDA approved heartworm prevention preparations are low enough to be used safely even in dogs that have two copies of the MDR1 mutation. It is only when these drugs are administered at high doses that dogs with the mutation will develop signs of toxicity. Attempting to use formulations of these drugs approved for use in large animals will increase the risk of overdosing the dog and causing severe toxicity, because it is difficult to accurately measure the small doses needed for dogs using these large animal formulations.


The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test offered by Washington State University that has been licensed to Mars Veterinary for use in the Wisdom Panel tests.

Exercise-Induced Collapse

Clinical Overview

Exercise-induced collapse (EIC) is an inherited disorder of nerve and muscle that was first identified in Labrador Retrievers. It is caused by a mutation in the DNM1 gene, and is characterized by exercise intolerance in otherwise normal dogs.

Clinical Signs and Severity

Signs are usually first noted in young dogs, most frequently between 5 months and 3 years of age. Affected dogs appear normal during low to moderate exercise, but develop clinical signs including weakness, wobbliness, and incoordination after strenuous exercise, particularly in the hind limbs. In severe cases, short-term full body collapse and muscle weakness can be noted. The episodes typically last 5-10 minutes, and most dogs will recover completely within 15-30 minutes.

Severity of the disorder is mild to moderate for the majority of dogs. Dogs are not painful during collapse or after recovery. Affected dogs are generally unable to continue training or competition, but can live relatively normal lives if exercise and excitement are limited.

Factors Contributing to Collapse in Affected Dogs

  • Ambient temperature or humidity much higher than what the dog is used to
  • Extreme excitement or stress
  • Exercise that is continuous, intense, and accompanied by high level excitement or anxiety

Commonly Affected Breeds

  • Boykin Spaniel
  • Chesapeake Bay Retriever
  • Curly Coated Retriever
  • Labrador Retriever
  • Old English Sheepdog
  • Pembroke Welsh Corgi
  • German Wirehaired Pointer
  • Mixed-breed


OPEN SWAB SLEEVE – Peel back the edges of the swab sleeve about 1 inch (not all the way) and remove swab by holding its handle. Do not touch the bristles. Save the sleeve to place the swabs in for mailing.
COLLECT CHEEK CELLS – Firmly roll the swab’s bristles between the inner surface of the cheek and gums for about 15 seconds for each swab. NOTE: DO NOT let your dog eat anything for about an hour before you do the test.
AIR DRY SWABS – Insert swab handle in the hole of the carton insert and allow swabs to dry for about five minutes. Repeat steps 1-3 for the second swab.
ACTIVATE YOUR KIT – Visit www.wisdompanel.com and click on the "Activate Your Kit" button at the top of the page. Fill out all the information, check it for accuracy and submit. You will receive an Activation Code Number that you need to write on the back of your Sample ID Sticker.
REINSERT DRY SWABS – Reinsert both dry swabs into the protective sleeve they came in. DO NOT reseal as this can cause bacterial growth.
SEAL THE CARTON – Place the sleeve with the swabs back into the carton it came in and seal.
MAIL TEST TO LAB – Pre-paid shipping label has already been placed on the carton.  Simply seal and place with the outgoing mail. IN APPROXIMATELY 2-3 WEEKS FROM THE TIME THE SAMPLE REACHES THE LAB YOU WILL BE EMAILED A LINK TO DOWNLOAD YOUR REPORT.

Foreign Dogs+

Is your dog from a country outside the contiguous US, UK, Canada, Australia or Germany?

The Wisdom Panel test was developed using pure breeds primarily from those found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than Canada, the UK, Australia, Germany, or mainland U.S., or you suspect that your dog’s ancestors are from outside these countries, his breed ancestry may not be well represented in our database.




by PowerReviews
Wisdom Panel

(based on 137 reviews)

Ratings Distribution

  • 5 Stars



  • 4 Stars



  • 3 Stars



  • 2 Stars



  • 1 Stars




of respondents would recommend this to a friend.

Most Liked Positive Review


Medical Concerns Thwarted

Initially I wanted to use the data to simply find out what mix my adopted foster dog was. He looked so unusual. The test came back so fast, it was a heaven sent!...Read complete review

Initially I wanted to use the data to simply find out what mix my adopted foster dog was. He looked so unusual. The test came back so fast, it was a heaven sent! My boy had Rocky Mountain Spotted fever when we pulled him from the shelter and after a nice recovery we decided to have a full workup done at the vet including an EKG. It came back unusual and we had his heart x-ray'd and found it a bit larger than it should be for a dog of his size. When the results came back from the DNA test, I gave a copy to my vet, who was instantly relieved and said there was nothing wrong with his heart. My boy is part Boxer on one whole side of his family tree. Boxers they have larger than normal hearts, naturally. He is also part Australian Shepherd which makes his chest more narrow than a boxers which put a bit of pressure on his heart which threw off his EKG, but for him, it was normal. Had I not known his DNA he could have had a lot of unnecessary treatments. Thank you!


Most Liked Negative Review


50% mixed doesn't tell me much

I sent DNA for one of my rescued dogs and it came back 50% mixed and only listed three specific breads (none of which he resembles). Big disappointment. 50% mixed doesn't tell me...Read complete review

I sent DNA for one of my rescued dogs and it came back 50% mixed and only listed three specific breads (none of which he resembles). Big disappointment. 50% mixed doesn't tell me anything I didn't already know.
Three Stars for easy to use and fast service but horrible results.

Reviewed by 137 customers

Displaying reviews 1-10

Back to top

Previous | Next »

(6 of 8 customers found this review helpful)


Much better than ten years ago

By Possum and Taters' mom

from Silver Spring MD

Verified Buyer

Comments about Wisdom Panel:

So much more precise and useful than when I had one run ten years ago on another dog. Thanks!

(4 of 8 customers found this review helpful)


You never know what you have

By debbie981

from Fort Dick, CA

Verified Buyer

Comments about Wisdom Panel:

Very easy to use, just brush against the inside of your pets cheek and send it in. We were always told that Buddy was fat or too big for what we thought he was. After getting his DNA test results back we now know why he is a big boy. We thought he was Lab and Border Collie (which he is) but he is also German Shepard and part Great Pyrenees. We love knowing what he really is instead of just guessing. Thank you Wisdom Panel.

(5 of 10 customers found this review helpful)


forgot password had trouble getting back

By mom

from Oneonta NY

Verified Buyer

Comments about Wisdom Panel:

Forgot password and very difficult to get back in. But otherwise interesting

(5 of 8 customers found this review helpful)


Mystery Solved

By Emma, the mutt's ,mom

from New Ulm. MN

Verified Buyer

Comments about Wisdom Panel:

Our Heinz 57 rescue dog has been a sweetheart from day one. We were so curious to put some identity to her lovable appearance and demeanor. Found out she is 25% pure dachshund which not one person ever predicted but all other components are truly mixed breed. Wisdom Panel was easy to use and I feel quite accurate. It helped to read several other reviews esp. the one from a biology pro who offered lots of insight.

(4 of 4 customers found this review helpful)


Everyone Had Guessed Wrong!

By Butterfly

from Richmond, VA

Verified Buyer

Comments about Wisdom Panel:

My pup was larger in body than most of her Beagle breed, longer, and so people assumed Dachshund. But no, that body came from a Boxer way back in her DNA that mated with a Chow Chow!!! When I could not get my report to come up, Wisdom worked with me via email and finally made a copy of my report and mailed it to me. That was going above and beyond. Very happy with the results and I had done this with my previous dog and was very happy with those results as well.

(5 of 6 customers found this review helpful)


Easy peasy, lemon squeezy

By Violet's lady maid

from Cincinnati, Ohio

Verified Buyer

Comments about Wisdom Panel:

The product was great. I only wish that the words Do not do test for 2 hours after dog eats, were on the very top of the box. I was reading all the step by step instructions and did not see that part until after I did the test. It seemed to work anyway.

(3 of 3 customers found this review helpful)


Quite a Surprise

By Kate

from Palm Desert, CA

Verified Buyer

Comments about Wisdom Panel:

I was very interested in knowing the breeds of my dog. He is very unique looking and no one can say what he is, including his vet and groomer. I loved finding out Ozzy is part Chow and Rat terrier and Australian Cattle dog, but the toy poodle is too far fetched! He is 45 pounds - a lot larger than a toy poodle! Nonetheless, I loved receiving his DNA quickly. Thank you.

(1 of 2 customers found this review helpful)


Found our dog was of totally different then we were told ,

By None

from Wheeling IL

Verified Buyer

Comments about Wisdom Panel:

I was totally surprised at what.I l,rned larned about our wonderful dog at firstI Thaught you.sent another dogs d n a ,but you.ran it a second only to arrive at the same conclusion my dog is larger and weighs more and doesn't even looks different! #!!! i

(1 of 1 customers found this review helpful)


Informational and fun

By Sled dog fan

from NH

Verified Buyer

Comments about Wisdom Panel:

Used this panel on an adopted/retired sled dog that was called an "Alaskan" dog (which basically means a mix of Northern breeds). I like the way it breaks down the mixture into percentages of each breed. The "known breed" breakdown and percentages seems pretty accurate for what we know about the history of this dog. The "mixed breed" designation (at 25% for this dog) is very broad in it's description however, and didn't seem to hold much useful information to us because of that. I am glad that we did the panel though. It's interesting and helpful to know the specific breeds we are dealing with in our new dog.

(2 of 2 customers found this review helpful)


Great and informative

By Eon

from Chicago

Verified Buyer

Comments about Wisdom Panel:

Highly recommended. Hardest part was getting the sample from my guy because he can be a brat about that sort of thing. Otherwise it was really incredible getting the results. Confirmed a lot of suspicions, but there were definitely surprises.

Displaying reviews 1-10

Back to top

Previous | Next »