Optimal Selection
Optimal Selection
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Wisdom Panel
®
 4.0 Canine Genetic Test

PRICE: $99.99
Purchase for US residents only.
This is NOT a breed detection product.
Mars Veterinary, the makers of Optimal Selection™ have partnered with Genoscoper Laboratories® of Finland to provide breeders with the ability to test for both breed-specific diseases and genetic diversity. Maintaining and increasing genetic diversity, may reduce the occurrence of inherited diseases and other known issues that can result from inbreeding.

Testing for genetic diversity can help breeders decrease the incidence of producing affected puppies with recessively inherited diseases, by reducing the likelihood of mating two carriers of the same disease to produce afflicted offspring. Optimal Selection offers breeders the world's first dog matchmaking tool that helps estimate the genetic impact of the planned mating pair on the puppies.

In order to maintain comprehensive breed health, along with the use of Optimal Selection, it is important to consider:
  1. Other health information from phenotypic tests, such as hip and eye examinations.
  2. Physical and behavioral characteristics of the breeding dogs.
  3. Results of any other applicable tests or competitive titles in the breed.
  4. Any additional recommendations for potential breeding dogs that may be outlined by the breed club.
 
To view a sample Optimal Selection™ report click here. This report is for a sample dog named "Optimus Canine". When you get to the page, do not click on any of the left-hand navigation. That will take you off the sample and you will not be able to get back in without revisiting this page and link. Feel free to share this link with other breeders you think may find this helpful.
 
1
OPEN SWAB SLEEVE – Peel back the edges of the swab sleeve about 1 inch (not all the way) and remove swab by holding its handle. Do not touch the bristles. Save the sleeve to place the swabs in for mailing.
2
COLLECT CHEEK CELLS – Firmly roll the swab’s bristles between the inner surface of the cheek and gums for about 15 seconds for each swab. NOTE: DO NOT let your dog eat anything or share a water dish with other dogs for about an hour before you do the test.
3
AIR DRY SWABS – Insert swab handle in the hole of the carton insert and allow swabs to dry for about five minutes. Repeat steps 1-3 for the second swab.
4
ACTIVATE YOUR KIT – Visit www.os.genoscoper.com/start and fill out all the information, check it for accuracy and submit. You will receive an Activation Code Number that you need to write on the back of your Sample ID Sticker.
5
REINSERT DRY SWABS – Reinsert both dry swabs into the protective sleeve they came in. DO NOT reseal as this can cause bacterial growth.
6
SEAL THE CARTON – Place the sleeve with the swabs back into the carton it came in and seal.
7
MAIL TEST TO LAB – Pre-paid shipping label has already been placed on the carton.  Simply seal and place with the outgoing mail. IN APPROXIMATELY 3-4 WEEKS FROM THE TIME THE SAMPLE REACHES THE LAB YOU WILL BE EMAILED A LINK TO VIEW YOUR REPORT.
Screen your dog for genetic mutations that can predict specific health conditions.  Optimal Selection™ currently tests for over 100 different diseases in each dog.  Click here to see the full list of diseases by breed.

Can the results be transferred to my breed registry?
DNA profiling is the primary type of DNA testing offered by breed registries in the US. DNA profiling is for the purpose of permanent identification of a dog (similar to a microchip) and for parentage testing; it does not screen for genetic diseases or genetic diversity. DNA profiling typically uses 13 microsatellite markers (often called STRs) to identify each dog, which are a different type of DNA marker than the one used in the Optimal Selection™ DNA test. Because different markers are used, in significantly greater numbers, and at different locations than those used in DNA profiling, results are not equivalent or transferrable. While Optimal Selection™  was not designed for DNA profiling for the purposes of verifying parentage or dog identity, it does identify every dog tested as a unique and recognizable individual.

Can I use my results for listing with OFA’s CHIC?
Yes! We are recognized by the Orthopedic Foundation for Animals (OFA) as an authorized DNA laboratory, and Optimal Selection results can be used for results listing on the Canine Health Information Center (CHIC). Instructions for submission of those results to OFA can be found on the Optimal Selection web portal under each dog’s account.

Can I test puppies?
Yes! Puppies can be tested, as their DNA results do not change with age. However, care must be taken that the dam’s or littermates’ DNA does not contaminate the sample. The process of nursing seeds the puppy’s mouth with DNA from the dam’s skin and the cells in the dam’s milk, so we do not recommend testing puppies who are still nursing. However, as soon as puppies are weaned, they can be safely tested following the usual guidelines. Optimal Selection dog profiles and accompanying results are designed to be easily shared or transferred to new owners when needed, free of charge, so an entire litter can be listed with Optimal Selection before they leave their birth home.

What breeds do you test for?
All breeds can be tested using an Optimal Selection DNA test and receive results about individual diversity and genetic health. However, certain breed statistics will not become available until a minimum number of individuals of that breed have been tested, in order to provide statistically significant population results.

Should I test my mixed-breed dog using Optimal Selection?
No. Optimal Selection is intended for purebred dogs only. If you have a mixed-breed dog and are interested in genetic health, we encourage you to test your dog using a Wisdom Panel® Canine DNA Test available on our website, or speak with your veterinarian about breed and genetic disease testing through Royal Canin® (Genetic Health Analysis™) or Banfield® Pet Hospitals (Canine Ganatic Analysis™).

How is thw Optimal Selection Genetic Health Index result different than coefficient of inbreeding or haplotypes?
The Optimal Selection Genetic Health Index (GHI) describes the relative health level of an individual dog’s genetic makeup in relation to previously tested dogs in the Optimal Selection database. This single number takes into account disease test results, the severity of the disease findings, as well as measured genetic diversity for that individual, obtained by examining over 1,800 locations spread over all chromosomes. The average dog has a GHI value of 100 - the healthier the dog, the higher the index.

NOTE:: The GHI value of a dog should not be used for breeding selections by itself, as mating of two dogs with a high GHI will not necessarily lead to healthier offspring. The Breeder Tool is designed to evaluate the genetic match between individuals, and provides a calculated projected GHI of the offspring to give breeders an easy way to compare possible mates to optimize the health and diversity of the litter.

Coefficient of inbreeding (COI), also known as coefficient of relationship, is a method of evaluating the degree of relatedness of two individuals based on pedigree records, not DNA testing. As a result, the COI is exactly the same for all puppies from a particular mating. Although genetic recombination in mammalian breeding is unpredictable, COI does not take into consideration the actual DNA inherited by an individual or variation between individuals within litters, nor does it correct for inaccuracies or unknowns in pedigree. DNA testing for diversity is individual-specific and can therefore be more sensitive, identifying opportunities for gains in diversity that could not otherwise be discerned by COI calculations.

Haplotype diversity refers to a form of DNA testing wherein sets or patterns of DNA markers are considered in breeding. This is popularly used in humans for the Y, or male chromosome, and is sometimes used in dogs. We believe evaluating genetic diversity across all markers and chromosomes is a more holistic, comprehensive approach to genetic diversity, although there are certainly conditions in which haplotype testing is more appropriate. The Optimal Selection Genetic Health Index provides all the information derived from an individual’s diversity and health evaluation in one easy to understand value, and in combination with the Breeder Tool, can allow breeders to make smarter breeding decisions. Unlike most haplotype testing, it does not require consultation with a genetics expert for result interpretation.

Are results shared with registries or other breeders?
No. Mars Veterinary takes client confidentiality seriously, and does not share testing information. Identities of submitting owners, as well as individual testing results, are not visible to anyone but the submitting owner, unless the owner chooses to share that information. In order to use the Optimal Selection Breeder Tool to find potential mates for breeding, the dog’s results must be made visible (public) to the global Optimal Selection community to see available dogs of the same breed. If an owner wishes to share his or her dog’s test results with another person, they can easily do so. The tested dog’s results will be visible to the submitting owner and with any person with whom they are shared, even if the dog does not participate in our Breeder Tool.

Can I upgrade my results?
At this time, testing upgrades are not available. If you have previously tested with us using a different product, such as Wisdom Panel® Canine DNA Test, or if new mutations or features become available for Optimal Selection for which you wish to test your dog, you must resubmit a new test. We apologize for any inconvenience this may cause.

Is Optimal Selection the same thing as MyDogDNA?
Mars Veterinary partnered with Genoscoper® Laboratories of Finland to offer a global breeder testing service, combining the knowledge and features of both companies’ prior products. This test and service is called Optimal Selection in the United States, offered by Mars Veterinary, and MyDogDNA™ in Europe, through Genoscoper Laboratories. Breeders in the US, Europe, and anywhere else these tests are offered can all communicate on the global web portal, which is ideal for breeds with an international following.

Can I submit semen from a deceased stud?
Yes. The Optimal Selection Genetic Breeding Analysis test is typically performed on cheek swab DNA samples. However, semen samples are also an excellent source of DNA if the dog is not available for swabbing.  Note that a small additional laboratory processing fee is required for semen samples.

The preferred semen sample is in the form of semen straws. However, pellets, vials or tubes of semen are also acceptable. A minimum of 50 microliters of semen is required for testing, although we recommend sending at least 100 microliters to ensure a sufficient quantity for testing. The volume contained in a semen straw varies, but any fully loaded straw will have more than the minimum 50 microliter volume.

Please contact Customer Service for a step-by-step guide to submit this sample type at customercare@marsveterinary.com or 888-K9 Pet Test (597-3883) and they would be happy to help you.

Do you analyze Dog Leukocyte Antigen (DLA) types?
Dog Leukocyte Antigens (DLA) are the canine equivalent of major histocompatibility complexes (MHCs) in humans; these are cell surface proteins expressed by cells of the immune system (white blood cells, or leukocytes). DLA types have received considerable attention in recent years, as they are suspected to play a critical role in autoimmune diseases, and we are aware of this research. However, because DLA types reflect a functional portion of the canine immune system, and its ability to fight infectious disease and cancer, until DLAs are better understood, we do not feel it prudent to select for or against certain DLA types, as there may be benefits or reasons for the presence or commonness of certain DLA types that are not known, and unforeseen consequences could occur that would impact the health of those dogs. Optimal Selection contains markers in the DLA region and incorporates these data into the dog’s diversity analysis, but does not actively select for DLA types in isolation. By emphasizing overall diversity in breeding, we feel similar benefits in immune health can be obtained. More research is certainly needed on this subject.