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Optimal Selection
Optimal Selection
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  • Optimal Selection
  • Optimal Selection
 


Wisdom Panel
®
 2.0 Genetic Breed Identification

PRICE: $95.00
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For centuries, dedicated breeders have worked to improve the temperament, conformation, and health of their purebred dogs. In doing so, the breeding community has unfortunately had to contend with the concerns of smaller litter size, puppy mortality, and health issues. Optimal Selection is here to help.

Optimal Selection is a tool to help breeders choose more optimal pairings by using cutting edge genetic technology to look beyond pedigrees, examine the chromosomes of potential breeding matches, and make more educated selections. Optimal Selection gives breeders “peace of mind” while taking away the guess work in pairing their potential breedings. This service helps breeders maintain their individual breed standards and desired traits while helping to improve their breeding programs and produce healthier dogs.

Endorsed by Breeders & Geneticists

"Optimal Selection helps breeders dedicated to selecting the best for both their program and their breed. We already select for best possible type, temperament, health, and soundness. Now, using Optimal Selection, we have a brilliant means for choosing genetic diversity as well. This is thrilling especially for breeders passionate about numerically endangered breeds."
Miriam Couto
Clossongrey Dandie Dinmont Terriers
"It is extremely exciting to have Optimal Selection offered as another tool for the breeders’ arsenal when evaluating potential breeding pairs. Added to phenotype consideration and pedigree analysis, individual dog’s genetic diversity is one more piece of the puzzle."
Cathy Nelson
Pennywise Dandie Dinmonts
"The opportunity to maximize genetic diversity within a breed while retaining desirable physical characteristics is a significant step forward. Actually reducing homozygosity, rather than basing choices on probability means that genetic diversity can be more successfully maintained and inbreeding depression can be reduced. The Optimal Selection tool is one that all breeders should consider implementing in their breeding programs."
Anita Oberbauer PhD
Canine Geneticist & Belgian Tervuren breeder
1
Select mates based on their family lines, temperament, conformation, and working ability.
2
Perform the Optimal Selection test for all dogs being considered for pairing. This requires a veterinarian supervised blood draw be taken for each dog and submitted using kits provided.
3
Within 2-3 weeks, the Individual Report is returned. Breeders can request Match Reports, compare the breeding scores for each potential mating, and consider any particular chromosomes of interest (e.g. chromosome 12 for the immune system) to make their breeding selection.
Breeds detected by Optimal Selection
How can Optimal Selection help my breeding program?
The primary objective of Optimal Selection is to help breeders make better breeding decisions based on science. Mars Veterinary recommends that breeders initially select the potential mates through the processes they have used in the past. Once that is completed, Optimal Selection should be used to further screen for the ultimate pairings. With this process breeders will maximize the potential genetic heterozygosity (aligning different haplotypes on each chromosome) from the dogs selected. Studies have shown that limited heterozygosity can cause decreased litter size and lead to greater health risks, thus increasing individual heterozygosity can help with these issues.
How does Optimal Selection work?
Optimal Selection uses a small blood sample to analyze a dog`s DNA on many key chromosomes. By comparing the potential sire’s and dam’s chromosomal similarities and differences, the breeder is given the opportunity to diversify the genetic makeup of their puppies and reduce the risk of recessive medical conditions while still selecting for the physical and behavioral traits that are important to them.
How should the Optimal Selection results be used?
The Optimal Selection analysis utilizes a scoring system based on the dog’s DNA that can be compared to multiple potential mates. Each potential mating will be given a breeding score based on the compatibility of the chromosomes analyzed. Lower scores are preferred since they show that these dogs are more likely to produce puppies with less risk of haplotype overlap in areas you are not selecting for while maintaining the traits that you are selecting for.

Many traits and diseases have been associated with specific genes or chromosomes. The following summarizes data presented in the research literature. This list is intended to provide guidelines for these traits and diseases; it may not be a complete list of traits/diseases or breeds that carry each. This list will expand as new information becomes available.

Chromosome Gene Trait/Disease Mode of Inheritance Allele has been identified in the following breeds Lab for Mutation Testing/ Comments
1   Brachycephaly   Affenpinscher, Boston Terrier, Boxer, Bulldog, French Bulldog, Japanese Chin, Pekingese, Pug, Shih Tzu, plus several more breeds  
2 PTPLA Centronuclear Myopathy Recessive Labrador Retriever VetGen
3 SLC2A9 Canine Hyperuricosuria Recessive Dalmatian, Bulldog, Black Russian Terrier VGL Davis
3 ADAMTS17 Lens Luxation Likely recessive but may affect some heterozygotes Jack Russell Terrier, Parson Russell Terrier, Miniature Bull Terrier, Lancahire Heeler, Tibetan Terrier  
5 BHD RCND (hereditary cancer) Dominant German Shepherd VetGen
5 HSF4 Cataract (Juvenile Hereditary) Recessive Boston Terrier VetGen
5 HSF4 Cataract (Hereditary) Recessive Staffordshire Bull Terrier, French Bulldog VetGen
5 NPHP4 cone-rod degeneration Recessive Standard Wirehair Dachshund  
5 HSF4 Cataract (Dominant Hereditary) Dominant Australian Shepherd Animal Health Trust
5 MCR1 Clear yellow/red Recessive Some breeds including Golden Retriever, Labrador Retriever  
5 MC1R Mask Dominant Some breeds including Boxer, French Bulldog, German Shepherd  
7 PKLR Pyruvate Kinase deficiency Recessive Basenji  
9 ADAMTSL2 Musladin-Lueke Syndrome Recessive Beagle VGL Davis
9 ARSG Neuronal Ceroid Lipofucinosis (late-onset) Recessive American Staffordshire Terrier (US and France)  
10 COMMD1 Copper Toxicosis Recessive Bedlington Terrier VetGen
10 SLC3A1 Cystinuria Recessive Newfoundland  
10 SILV Merle Semi-dominant Australian Shepherd, Border Collie, Cardigan Welsh Corgi, Chihuahua, Cocker Spaniel, Great Dane, plus several more breeds  
11 TYRP1 Black Dominant Most breeds  
11 TYRP1 Brown/Chocolate Recessive Some breeds including Labrador Retriever, Chesapeake Bay Retriever 3 separate alleles identified
12 multiple Major histocompatibility complex (immune genes)   All breeds  
13 RSPO2 "Furnishings" (moustache and eyebrows typically observed in wire-haired dogs Dominant Several breeds including Airedale Terrier, Australian Terrier, Bearded Collie, Bichon Frise, Black Russian Terrier, Border Terrier, Bouvier, Briard, Brussels Griffon, Cairn Terrier, Chinese Crested, Dachshund, Dandie Dinmont Terrier, German Wirehaired Pointer, Giant Schnauzer, Glen of Imaal Terrier, Havanese, Irish Terrier, Irish Wolfhound, Kerry Blue Terrier, Lhasa Apso, Maltese, Norfolk Terrier, Old English Sheepdog, Petit Basset Griffon Vendeen, Portuguese Water Dog, Scottish Deerhound, Shih Tzu, Silky Terrier, Soft Coated Wheaten Terrier, Spinone Italiano, Standard Poodle, Standard Schnauzer, Welsh Terrier, West Highland White Terrier, Wire Fox Terrier, Wirehaired Pointing Griffon, Yorkshire Terrier  
14 ABCB4 Gallbladder Mucoceole Dominant w/incomplete penetrance Shetland Sheepdog, Cocker Spaniel, Cairn Terrier, Pomeranian Research on-going at University of Washington
15 PPT1 Neuronal Ceroid Lipofucinosis (early-onset) Recessive Miniature Dachshund University of Missouri/OFA
15 RPGRIP1 cord1 - PRA Recessive English Springer Spaniel, Miniature Shorthair Dachshund, Miniature Longhair Dachshund VetGen
15 IGF1 Size/weight (other genes involved)   Most breeds  
16 CLCN1 Myotonia Congenita Recessive Miniature Schnauzer  
16 CBD103 Brindle Dominant Some breeds including Akita, American Staffordshire Terrier, Boston Terrier, Bouvier, Boxer, Bulldog, Bullmastiff, Cardigan Welsh Corgi, French Bulldog, Great Dane, Greyhound, Mastiff, Neapolitan Mastiff, Plott, Scottish Terrier, Staffordshire Bull Terrier  
17 striatin Boxer cardiomyopathy Semi-dominant Boxer University of Washington
17 TPO Congenital Hypothyroidism with Goiter Recessive Toy Fox Terrier, Rat Terrier Michigan State University
18 Fgf4 retrogene Chondrodysplasia Semi-dominant Several breeds including Basset Hound, Carin Terrier, Cardigan Welsh Corgi, Chihuahua, Dachshund, Dandie Dinmont Terrier, Glen of Imaal Terrier, Grand Basset Griffon Vendeen, Havanese, Japanese Chin, Lancashire Heeler, Norwich Terrier, Pekingese, Pembroke Welsh Corgi, Petit Basset Griffon Vendeen, Scottish Terrier, Shih Tzu, Skye Terrier, Swedish Valhund, Tibetan Spaniel, West Highland White Terrier, Yorkshire Terrier  
20 AP3 Cyclic Neutropenia Recessive Collie VetGen
20 MITF White spotting Semi-dominant several breeds  
21 CTSD Neuronal Ceroid Lipofucinosis Recessive American Bulldog, English Setter VetGen
22 FVII Factor VII deficiency Recessive Beagle, Alaskan Klee Kai  
24 ASIP Fawn (ay) Dominant Several breeds including Akita, Basset Hound, Brittany, Cardigan Welsh Corgi, Chinese Shar Pei, Collie, Dachshund, Eurasier, Finnish Lapphund, Golden Retriever, Large Munsterlander, Pembroke Welsh Corgi, Russell Terrier, Saluki, Shetland Sheepdog, Viszla  
24 ASIP Wolf sable (aw) Dominant Several breeds including Akita, Alaskan Malamute, Border Collie, Brittany, Chinese Shar Pei, Dachshund, Eurasier, German Shepherd, German Shorthair Pointer, German Wirehair Pointer, Golden Retriever, Keeshond, Miniature Schnauzer, Norwegian Elkhound, Siberian Husky, Standard Schnauzer, Swedish Vallhund, Viszla  
24 ASIP Tan points (at) Recessive Several breeds including Beagle, Border Collie, Cardigan Welsh Corgi, Chihuahua, Collie, Dachshund, Doberman Pinscher, German Shepherd, Golden Retriever, Labrador Retriever, Miniature Pinscher, Pembroke Welsh Corgi, Rottweiler, Russell Terrier, Saluki, Shetland Sheepdog  
24 ASIP Recessive Black (a) Recessive Border Collie, Eurasier, German Shepherd, Shetland Sheepdog  
25 MLPH Dilution Recessive Some breeds including Doberman Pinscher, Weimaraner  
27 vWF Type I vWD Dominant w/variable penetrance Bernese Mountain Dog, Coton de Tulear, Dobermann Pinscher, German Pinscher, Kerry Blue Terrier, Manchester Terrier, Papillon, Pembroke Welsh Corgi, Poodle VetGen
27 vWF Type II vWD Recessive Collie, German Longhaired Pointer, German Shorthaired Pointer, German Wirehaired Pointer, Pointer VetGen
27 vWF Type III vWD Recessive Scottish Terrier, Shetland Sheepdog, Kooikerhondje VetGen
27 PFKM Phosphofructokinase deficiency Recessive English Springer Spaniel, Cocker Spaniel, Whippet  
27 KRT71 Curly coat Dominant Airedale Terrier, Bichon Frise, Border Collie, Boykin Spaniel, Chesapeake Bay Retriever, Chihuahua, Havanese, Kuvasz, Leonberger, Maltese, Portuguese Water Dog, Soft Coated Wheaten Terrier, Standard Poodle, Welsh Terrier, Wire Fox Terrier *Note: in some breeds, the genotype does not explain the observed phenotype
29 PDP1 Pyruvate Dehydrogenase Phosphatase I Recessive Clumber Spaniel, Sussex Spaniel VetGen
31 SOD1 Degenerative Myelopathy Recessive German Shepherds, Rhodesian Ridgebacks, Boxers, Pembroke Welsh Corgis, Cardigan Welsh Corgi, Chesapeake Bay Retrievers, Standard Poodles, American Eskimo, Bernese Mtn Dog, Golden Retriever, Great Pyrenees, Kerry Blue Terrier, Pug, Shetland Sheepdog, Soft Coated Wheaten Terrier, Wire Fox Terrier University of Missouri/OFA
32 FGF5 Shorthair Dominant Afghan Hound, Airedale Terrier,Akita, Alaskan Malamute, Australian Shepherd, Australian Terrier, Basenji, Basset Hound, Beagle, Bloodhound, Border Collie, Border Terrier, Boston Terrier, Boxer, Brussels Griffon, Bulldog, Bullmastiff, Cairn Terrier, Cardigan Welsh Corgi, Chesapeake Bay Retriever, Chihuahua, Chinese Crested, Chow Chow, Collie, Dachshund, Dandie Dinmont Terrier, Doberman Pinscher, Entlebucher Mountain Dog, German Shepherd, German Shorthair Pointer, Giant Schnauzer, Glen of Imaal Terrier, Great Dane, Greater Swiss Moutain Dog, Greyhound, Irish Terrier, Irish Wolfhound, Italian Greyhound, Japanese Chin, Kerry Blue Terrier, Kuvasz, Labrador Retriever, Mastiff, Norfolk Terrier, Pembroke Welsh Corgi, Petit Basset Griffon Vendeen, Pharaoh Hound, Pug, Rottweiler, Saint Bernard, Saluki, Samoyed, Scottish Deerhound, Scottish Terrier, Silky Terrier, Smooth Fox Terrier, Spinone Italiano, Staffordshire Bull Terrier, Standard Schnauzer, Swedish Valhund, Tibetan Mastiff, Toy Fox Terrier, Welsh Terrier, West Highland White Terrier, Whippet, Wire Fox Terrier, Yorkshire Terrier *Note: in some breeds, the genotype does not explain the observed phenotype
32 FGF5 Longhair Recessive Afghan Hound, Airedale Terrier, Alaskan Malamute, American Eskimo, American Water Spaniel, Australian Shepherd, Bearded Collie, Belgian Tervuren, Bernese Mountain Dog, Bichon Frise, Black Russian Terrier, Border Collie, Borzoi, Bouvier, Boykin Spaniel, Briard, Brittany, Carin Terrier, Cardigan Welsh Corgi, Cavalier King Charles Spaniel, Chihuahua, Chinese Crested, Chow Chow, Clumber Spaniel, Cocker Spaniel, Collie, Dachshund, English Cocker Spaniel, English Setter, Flat-Coated Retriever, German Shepherd, Giant Schnauzer, Golden Retriever, Gordon Setter, Great Pyrenees, Havanese, Irish Water Spaniel, Japanese Chin, Kerry Blue Terrier, Kuvasz, Leonberger, Lhasa Apso, Maltese, Newfoundland, Old English Sheepdog, Papillon, Pekingese, Pomeranian, Portuguese Water Dog, Rottweiler, Saint Bernard, Saluki, Samoyed, Scottish Deerhound, Shih Tzu, Silky Terrier, Soft Coated Wheaten Terrier, Standard Poodle, Sussex Spaniel, West Highland White Terrier, Yorkshire Terrier