Clinical signs of this disease emerge very acutely in dogs under one year of age. Early signs of the disease include noisy respiration, increased respiratory rate, vomiting, and weight loss. The disorder is unresponsive to treatment and quickly develops into severe respiratory distress that can be accompanied with other severe conditions, such as pneumomediastinum, hiatal herniation, or gastroesophageal intussusception. The disorder is unresponsive to treatment and affected dogs die or are euthanized between 1-6 weeks after the onset of respiratory signs. Some affected dogs have been reported to exhibit other developmental anomalies such as hydrocephalus or renal aplasia. These anomalies are not directly linked to the respiratory signs and affected dogs usually grow and develop normally until the onset of respiratory signs.

All described cases of the disorder have died or were euthanized due to unresponsiveness to treatment and clinical severity. Treatment should be targeted at maintaining fluid balance and oxygenation. Anti-inflammatory treatment may be of help. The prognosis is poor.

There are many responsibilities to consider when breeding dogs. Regardless of test results it is important that your dog is in good general health and that you are in a position to care for the puppies if new responsible owners are not found. For first time or novice breeders, advice can be found at most kennel club websites.

This disease is autosomal recessive meaning that two copies of the mutation are needed for disease signs to develop. A carrier dog with one copy of the ARDS mutation can be safely bred with a clear dog with no copies of the ARDS mutation. About half of the puppies will have one copy (carriers) and half will have no copies of the ARDS mutation. Puppies in a litter which is expected to contain carriers should be tested prior to breeding. Carrier to carrier matings are not advised as the resulting litter may contain affected puppies. Please note: It is possible that disease signs similar to the ones caused by the ARDS mutation could develop due to a different genetic or clinical cause.