Leo Dog

Disease Screening

Scientific Legacy

Multi-drug Sensitivity – MDR1

MDR1 or Multi-drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed-breed dogs. This mutation can have a significant impact on drug sensitivity. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

Technology Licensed By

The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test that has been licensed exclusively to Mars Veterinary in the United States for use in the Wisdom Panel tests.



Exercise-induced Collapse - EIC

Exercise-induced Collapse, or EIC is a genetic disorder that affects nerve and muscle it was first identified in Labrador Retrievers and has been found in many of the retrieving breeds and mixed-breed dogs with retriever ancestry. EIC is caused by a mutation in the DNM1 gene, and is usually first seen in dogs between five months and three years of age. Dogs who are affected may appear normal during low to moderate exercise, but as the name would suggest, develop weakness, wobbliness, and incoordination after strenuous exercise, particularly in the hind limbs. In severe cases, they may have short-term full body collapse and muscle weakness. These episodes typically last 5-10 minutes and most dogs will recover completely within 15-30 minutes.

Some of the factors that can contribute to EIC are a higher temperature or humidity that the dog is used to; extreme stress or excitement; and exercise that is continuous, intense and accompanied by a high level of excitement or anxiety. While the severity of EIC is mild to moderate for the majority of dogs and dogs are not painful during collapse or after recovery, affected dogs are generally unable to continue training or competition. They can live relatively normal lives if exercise and excitement are limited.